The crew of the plane alerted health authorities on the ground in Barajas after the passenger said he didn't feel well, according to Spanish news agency Europa Press.
The plane carrying 156 passengers and seven crew members left Charles de Gaulle in Paris at 9.35am and arrived at 11.30am, national daily El País reported.
Sources at Air France told Europa Press passengers had disembarked "normally".
An Air France spokesperson told The Local the passenger — who was coming from Nigeria and was on a connecting flight from Paris, according to Spanish broadcaster RTVE — had now been isolated for medical checks.
He did not have fever, the airline said, contradicting some Spanish media reports.
"Initial indications are that it's not a case of Ebola," the airline spokesman told The Local, although he said medical investigations were ongoing.
"We understand the passenger did not have a temperature."
The plane is being kept in Madrid, and disinfected as a precaution, the Air France spokesperson said.
The aircraft is currently at a remote parking by at Madrid airport, and authorities are waiting for at least one ambulance so that the isolated passenger can be transferred to Madrid's Carlos III hospital, news agency Efe has reported.
He will remain at the facility until tests confirming whether has Ebola or not have been carried out, El Mundo have reported.
Carlos III is the hospital where the Spanish nursing assistant with Ebola, Teresa Romero, is currently receiving treatment.
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